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August 23, 2020

WHAT IS PREDICTIVE GENETICS?

Predictive genetics is a genetic screening in which we read our DNA using an advanced technology that help us predict years before the development of lifestyle diseases and clinical disorders. It help us give a clue what diet suits us and what diet doesn’t. It also gives us a glimpse into our intelligent quoefficient (IQ), Emotional quoefficient (EQ), hereditary talents and even personality traits. It also predicts what all drugs suits our body and what all drugs doesn’t. In addition, it can also predict, if you are susceptible to get a cancer, if there is a cancer already running in your family. It also give insights into our athletic performance and what kind of sports injury we are likely to get. It can also predict, our addiction to certain substances in advance, thereby helping us to design our life, years in advance before we get occupied with bad habbits. This help us to have a healthy and a long perfect life that we dream to have in our life. So, let us learn from scratch, what is really predictive genetics; starting right from DNA.

What is DNA and how it controls our life?

Our human body is made of cells. Our cells has a nucleus as its brain. In that nucleus, contains chromosomes. Chromosomes are made of DNA and DNA have genes as its fundamental structural and functional unit. A gene basically a codon. The codon comprises of a combination of 4 different nucleotides like Adenine, Thymine, Cytosine and Guanine. The combination of different nucleotides in our genes determines our personality, intelligence, health and physical appearance.

For example:
CAG codon in the gene codes for amino acid glutamate, which is an essential neurotransmitter in the brain, that conveys information from neuron to another neuron.

Why not all DNA are the same and why your DNA is unique?

DNA in every human beings are not the same and there is something in it that makes you totally unique; and that is known as the Single nucleotide polymorphism. Single nucleotide polymorphism is also known as SNP, is variation in a genetic sequence that affects only one of the basic building blocks like adenine, guanine , thymin or cytosine in a segment of a DNA. SNP exists in more than 1 percent of a population in the world. Around 335 million SNP have been discovered in human genome till now.

For example:

SNP is the substitution of a cytosine (C) for a guanine (G) in the nucleotide sequence AACGAT, thereby producing the sequence AACCAT. If ‘AACGAT’ coded for one particular enzyme or protein, the substituted SNP ‘AACCAT’ will code for another enzyme or protein. This entirely changes how things work in your body, making you unique from others.

Can we detect SNP in your DNA?

Off course, yes! We are able to read this SNP with ‘microarray’ technology. In microarray procedure, we take this genetic reading through three phases namely, DNA hybridization, fluorescent microscopy and solid surface DNA capture. SNP microarray is the hybridization of fragmented single-stranded DNA to arrays containing hundreds of thousands of unique nucleotide probe sequences. Each probe is designed to bind to a target DNA subsequence. A specialized equipment is then used to produce a measure of the signal intensity associated with each probe and its target after hybridization. The signal intensity depends upon the amount of target DNA in the sample, as well as the affinity between target and probe. Extensive processing and analysis of these raw intensity measures, yield SNP genotype inferences. This is how SNP are measured with Microarray technology. It is a bit technical stuff, but it is as simplest it can be said scientifically!

What are the benefits of measuring this SNP in your DNA with this technology?

By measuring SNP in your DNA, we are able to

1. Predict lifestyle diseases and clinical disorders in advance, before it ruins our life in future.
2. Predict the possibility for a cancer, years before it can happen.
3. Find diet that suits your genome and diet that will not suit your genome.
4. Find drugs that are compatible with your genome and drugs that are not compatible with your genome.
5. Find genetic predisposition to certain personality traits that you are bother aware and unaware of.
6. Find genetic potential for your Intelligent quoefficient and Emotional Quoefficient.
7. Find unexplored talents and unique abilities in your genetic sequence.

Why you should screen your DNA with microarray technology?

You should take this once in a lifetime test to know what’s written in your DNA, that has already predetermined your intelligence, personality and emotional makeup. This enables us to chose the appropriate careers, friends and situations in life that enables us to grow. It also give us a detailed picture of diseases and disorders, you will have in your life time. This enables us to design your health by avoiding things that triggers expression of genes that causes diseases and disorders. It also help us to design the diet and drugs you must have. This help us to avoid the kind of diet that harms you and post the kind of diet that promotes your health. This also help us to opt for the most appropriate drugs that will accelerate healing process and avoid drugs that might cause hypersensitivity or harmful effects on long term. In sum, we will be able to design your life with genomics, once in for all as there is nothing beyond the genetic code. We can bring changes in the genetic expression once it is decoded through microarray technology, through the conductive environment, with which we will design our life through many scientifically proven interventions that intervenes our lifestyle, diet and performance.

Authors:

Dr. Aseeb M.Phil, PhD (Biotechnology)
Dr. Fahad MBBS, PgdipDiab(UK), MRCP (UK) 2

Genes & U
Global scientific biotech research pvt.Ltd
Mumbai, India.

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